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Recombinant Human Probable DNA dC->dU-editing enzyme APOBEC-3A(APOBEC3A)AP73798

Catalog No.	Package Size	Price
AP73798-1	10ug	$105.00
AP73798-2	50ug	$260.00
AP73798-3	100ug	$454.00
AP73798-4	200ug	$735.00
AP73798-5	500ug	$1240.00
AP73798-6	1mg	$1980.00

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Availability: The lead time is currently 7-30 days.

Description

Product Name Recombinant Human Probable DNA dC->dU-editing enzyme APOBEC-3A(APOBEC3A)
Brief Description Recombinant Protein
Host Species E.coli
Target Name APOBEC3A
Alternative Names Phorbolin-1
Accession No. Uniprot ID: P31941
Target Species Hu
SDS-PAGE MW 39kDa
Target Length Full Length,1-199aa
Tag Info N-terminal 6xHis-SUMO-tagged
Target Sequence MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Formulation Tris-based buffer,50% glycerol
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20˚C/-80˚C. The shelf life of lyophilized form is 12 months at -20˚C/-80˚C.

Application Details

Greater than 90% as determined by SDS-PAGE.

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Background

DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Regerences

"Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1."Madsen P.P., Anant S., Rasmussen H.H., Gromov P., Vorum H., Dumanski J.P., Tommerup N., Collins J.E., Wright C.L., Dunham I., Macginnitie A.J., Davidson N.O., Celis J.E.J. Invest. Dermatol. 113:162-169(1999)

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